Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis from primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma.
نویسندگان
چکیده
© 2014 The Authors. doi: 10.2340/00015555-1806 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Lymphomatoid papulosis (LyP) is characterised by a chronic course of years to decades of recurrent papulonodular lesions, each of which undergoes spontaneous regression after weeks or months (1). Recently LyP type D was identified as a new histolopathological variant simulating a primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (pCAE-CD8+ CTCL) (2). Despite histologically alarming features, the patients have a clinical presentation and indolent course that are similar to those with typical cases of LyP.
منابع مشابه
Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, cl...
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toxic T-cell phenotype. J Invest Dermatol 1997; 109: ing, T-cell-receptor gene rearrangement and electron microscopic studies. Br J Dermatol 1992; 126: 404–408. 636–640. 7. El Shabrawi-Caelen L, Cerroni L, Kerl H. The clinicopa10. Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermothologic spectrum of cytotoxic lymphomas of the skin. Semin C...
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CHOEP: chemotherapy with cyclophosphamide doxorubicin, etoposide, vincristine, and prednisone CTCL: cutaneous T-cell lymphoma HLA: human leukocyte antigen HSCT: hematopoietic stem cell transplantation LyP: lymphomatoid papulosis INTRODUCTION We report a case of a fulminant cutaneous cytotoxic T-cell lymphoma nonresponsive to chemotherapy but showing durable complete response to a fast sequence ...
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According to the WHO/EORTC classification, lymphomatoid papulosis (LyP) is a recurrent, selfhealing papular eruption belonging to the spectrum of cutaneous CD30+ lymphoproliferative disorders. The neoplastic cell is typically a CD4+ T-lymphocyte, also manifesting CD30 expression. Three main histologic subtypes are recognized: type A (histiocytic), type B (mycosis fungoides-like), and type C (an...
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Primary cutaneous CD30(+) lymphoproliferative disorders (CD30(+) LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30(+) LPDs are characterized by an excellent prognosis. Although a broad spectrum of ...
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عنوان ژورنال:
- Acta dermato-venereologica
دوره 94 5 شماره
صفحات -
تاریخ انتشار 2014